| Critical review of the current literature on the safety of sucralose |
Food Chem Toxicol |
Review |
Toxicology, Sweeteners, Food additives, Flavouring |
| Mutagenicity and genotoxicity studies of aspartame |
Regul Toxicol Pharmacol |
Primary, in vitro |
Sweeteners, Toxicology, Food additives, Flavouring |
| Risk Assessment Paradigm for Glutamate |
Ann Nutr Metab |
Review |
Toxicology, Flavouring, Food additives, Amino acid |
| Challenges in the design, interpretation, and reporting of randomized controlled clinical studies on the health effects of whole foods |
Appl Physiol Nutr Metab |
Review |
Study designs |
| Lactobacillus rhamnosus MP108: Toxicological evaluation |
J Food Sci |
Primary, in vivo |
Toxicology, Probiotics, GRAS, Natural Health Products |
| Low-/No-Calorie Sweeteners: A Review of Global Intakes |
Nutrients |
Expert Opinion |
Amino acid, Food additives, Sweeteners, GRAS |
| The Safety and Regulatory Process for Amino Acids in Europe and the United States |
J Nutr |
Expert Opinion |
Toxicology, Flavouring, Amino acid, GRAS, Novel Foods |
| Determinants of Sweetness Preference: A Scoping Review of Human Studies |
Nutrients |
Review |
Sweeteners |
| A hard look at FDA's review of GRAS notices |
Regul Toxicol Pharmacol |
Expert Opinion |
GRAS |
| Assessing the in vivo data on low/no-calorie sweeteners and the gut microbiota |
Food Chem Toxicol |
Review |
Flavouring, Sweeteners, Amino acid |
| Evaluation of aspartame cancer epidemiology studies based on quality appraisal criteria |
Regul Toxicol Pharmacol |
Systematic review |
Sweeteners, Study designs |
| Toxicological safety evaluation of pasteurized Akkermansia muciniphila |
J Appl Toxicol |
Primary, in vivo |
Toxicology, Probiotics |
| An appraisal of the published literature on the safety and toxicity of food-related nanomaterials |
Crit Rev Toxicol |
Review |
Nanomaterials, Toxicology, Study designs |
| Perspectives on the genotoxic risk of styrene |
J Toxicol Environ Health B Crit Rev |
Review |
Toxicology, Genotoxicity |
| Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid dose-dependently reduce fasting serum triglycerides |
Nutr Rev |
Systematic review |
Oil, Study designs |
| The safety and regulatory process for low calorie sweeteners in the United States |
Physiol Behav |
Review |
Toxicology, Flavouring, Food additives, Sweeteners |
| Safety evaluation of Neurospora crassa mycoprotein for use as a novel meat alternative and enhancer |
Food Chem Toxicol |
Review |
Toxicology, Alternative proteins |
| Alternatives to animal testing in toxicity testing: Current status and future perspectives in food safety assessments |
Food Chem Toxicol |
Review |
Toxicology, Study designs |
| Influence of observational study design on the interpretation of cancer risk reduction by carotenoids |
Nutr Rev |
Systematic review |
Toxicology, Food additives, Study designs |
| A Narrative Review of Childhood Picky Eating and Its Relationship to Food Intakes, Nutritional Status, and Growth |
Nutrients |
Review |
|
| Safety assessment of the post-harvest treatment of button mushrooms (Agaricus bisporus) using ultraviolet light |
Food Chem Toxicol |
Review |
Toxicology |
| Safety assessment of Streptococcus salivarius M18 a probiotic for oral health |
Benef Microbes |
Primary, in silico |
Toxicology, Probiotics, Bioinformatic analysis |
| Bifidobacterium longum subsp. infantis YLGB-1496-Toxicological evaluation |
J Appl Toxicol |
Primary, in vivo |
Toxicology, Probiotics, Genotoxicity, chromosomal aberration assay, Ames test |
| Vitamin D4 in mushrooms |
PLoS One |
Primary, chemical analysis |
Novel Foods, NDIN, GRAS, Vitamins, whole food |
| An evaluation of the possible carcinogenicity of bisphenol A to humans |
Regul Toxicol Pharmacol |
Review |
Toxicology, Genotoxicity, Carcinogenicity, Metabolism |
| Review of subchronic/chronic toxicity of antimony potassium tartrate |
Regul Toxicol Pharmacol |
Review |
Minerals, Subchronic toxicity study, Chronic toxicity |
| Regulatory landscape of alternatives to animal testing in food safety evaluations with a focus on the western world |
Regul Toxicol Pharmacol |
Review |
Toxicology, Study designs, New Approach methodologies (NAMs), New approach methodologies (NAMs) |
| Safety assessment of glutaminase from Aspergillus niger |
Food Sci Nutr |
Primary, in vivo |
Subchronic toxicity study, Enzymes, Amino acid, Genotoxicity, Ames test, chromosomal aberration assay |
| Preclinical safety evaluation of Lipase OF from Candida cylindracea |
J Appl Toxicol |
Primary, in vivo |
Subchronic toxicity study, Enzymes, Ames test, chromosomal aberration assay |
| Low digestible carbohydrates (polyols and lactose): significance of adrenal medullary proliferative lesions in the rat |
Regul Toxicol Pharmacol |
Review |
Toxicology, Dietary fibers, Prebiotics, Regulatory assessment |
| The Threshold of Toxicological Concern (TTC) in risk assessment |
Toxicol Lett |
Review |
Toxicology, Bioinformatic analysis |
| A comprehensive review of oral glucosamine use and effects on glucose metabolism in normal and diabetic individuals |
Diabetes Metab Res Rev |
Review |
Metabolism |
| A comparison of the LDL-cholesterol lowering efficacy of plant stanols and plant sterols over a continuous dose range: results of a meta-analysis of randomized, placebo-controlled trials |
Prostaglandins Leukot Essent Fatty Acids |
Systematic review |
Toxicology, Fatty acids, Meta-anaysis |
| A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties |
Food Chem Toxicol |
Review |
Carcinogenicity, Genotoxicity, Toxicology, Flavonoids |
| The effects of almond consumption on fasting blood lipid levels: a systematic review and meta-analysis of randomised controlled trials |
J Nutr Sci |
Systematic review |
Meta-anaysis, whole food |
| Is Splenda, or Sucralose, Causally Linked to Inflammatory Bowel Disease? |
Inflamm Bowel Dis |
Review |
Sweeteners |
| Toxicology review and risk assessment of resorcinol: thyroid effects |
Regul Toxicol Pharmacol |
Review |
Chronic toxicity |
| Impact of low v. moderate intakes of long-chain n-3 fatty acids on risk of coronary heart disease |
Br J Nutr |
Review |
Toxicology, Oil, Fatty acids, Clinical trials |
| Genotoxicity, acute, and subchronic toxicity evaluation of dried Neurospora crassa protein-rich biomass |
Toxicol Res (Camb) |
Primary, in vivo |
Subchronic toxicity study, Genotoxicity |
| Fructose-Glucose Composite Carbohydrates and Endurance Performance: Critical Review and Future Perspectives |
Sports Med |
Review |
Sweeteners |
| Review of evidence relating to occupational exposure limits for alpha-diketones and acetoin, and considerations for deriving an occupational exposure limit for 2,3-pentanedione |
Crit Rev Toxicol |
Review |
Toxicology, Chronic toxicity, Occupational exposures, Inhalational toxicity |
| Liver biomarkers in adults: Evaluation of associations with reported green tea consumption and use of green tea supplements in U.S. NHANES |
Regul Toxicol Pharmacol |
Review |
Natural Health Products, Flavonoids, NDIN |
| Viadent usage and oral leukoplakia: a spurious association |
Regul Toxicol Pharmacol |
Review |
Toxicology, Genotoxicity, Carcinogenicity |
| A reassessment of risk associated with dietary intake of ochratoxin A based on a lifetime exposure model |
Crit Rev Toxicol |
Review |
Toxicology, Chronic toxicity, Genotoxicity, Carcinogenicity |
| Neonatal subchronic toxicity and in vitro genotoxicity studies of the human-identical milk oligosaccharide 3-fucosyllactose |
J Appl Toxicol |
Primary, in vivo |
Subchronic toxicity study, Ames test, Toxicology, Dietary fibers |
| Preclinical safety evaluation of the human-identical milk oligosaccharide lacto-N-tetraose |
Regul Toxicol Pharmacol |
Primary, in vivo |
Dietary fibers, Prebiotics, Toxicology, Genotoxicity, Subchronic toxicity study |
| Safety evaluation of AMP deaminase from Aspergillus oryzae |
Food Chem Toxicol |
Primary, in vivo |
Toxicology, Genotoxicity, Enzymes, Subchronic toxicity study |
| Low- and no-calorie sweetener intakes in the Brazilian population estimated using added sugar substitution modelling |
Food Addit Contam Part A Chem Anal Control Expo Risk Assess |
Primary, in silico |
Sweeteners, Dietary exposure |
| Reproductive and developmental toxicity screening study of an acetone extract of rosemary |
Regul Toxicol Pharmacol |
Primary, in vivo |
Reproductive toxicity, Developmental toxicity, Food additives, Flavouring |
| Safety evaluation of arabinase (arabinan endo-1,5-α-L-arabinanase) from Aspergillus tubingensis |
Food Sci Nutr |
Primary, in vivo |
Enzymes, Genotoxicity, Subchronic toxicity study, Ames test, Chromosomal aberration assay |
| Safety assessment of a solid lipid curcumin particle preparation: In vitro and in vivo genotoxicity studies |
J Appl Toxicol |
Primary, in vivo |
Chromosomal aberration assay, Ames test, Subchronic toxicity study |
| Safety evaluation of the human-identical milk monosaccharide, l-fucose |
Regul Toxicol Pharmacol |
Primary, in vivo |
Human milk oligosaccharides (HMO), Reproductive toxicity, Developmental toxicity, Subchronic toxicity study, Toxicology |
| Lipid-soluble green tea extract: Genotoxicity and subchronic toxicity studies |
Regul Toxicol Pharmacol |
Primary, in vivo |
Toxicology, Flavonoids, Genotoxicity, Chromosomal aberration assay, Subchronic toxicity study |
| Genotoxicity and subchronic toxicity studies of supercritical carbon dioxide and acetone extracts of rosemary |
Regul Toxicol Pharmacol |
Primary, in vivo |
Toxicology, Genotoxicity, Ames test, Subchronic toxicity study, Flavouring, Food additives |
| Contribution of 100% Fruit Juice to Micronutrient Intakes in the United States, United Kingdom and Brazil |
Nutrients |
Primary, in silico |
Dietary exposure |
| Safety evaluation of fish protein hydrolysate supplementation in malnourished children |
Regul Toxicol Pharmacol |
Primary, Clinical trial |
Amino acid, Protein, Toxicology |
| Subchronic toxicity evaluation of aloesin |
Regul Toxicol Pharmacol |
Primary, in vivo |
Toxicology, Subchronic toxicity study |
| Subchronic toxicity evaluation of potato protein isolates |
Food Chem Toxicol |
Primary, in vivo |
Toxicology, Subchronic toxicity study, Protein |
| Genotoxicity, acute and subchronic toxicity evaluation of savory food ingredients |
Regul Toxicol Pharmacol |
Primary, in vivo |
Flavouring, Food additives |
| Subchronic (90-day) toxicity assessment of Somacy-FP100, a lipopolysaccharide-containing fermented wheat flour extract from Pantoea agglomerans |
J Appl Toxicol |
Primary, in vivo |
Toxicology, Subchronic toxicity study |
| Broccoli seed extract: Genotoxicity and subchronic toxicity studies |
Regul Toxicol Pharmacol |
Primary, in vivo |
Toxicology, Genotoxicity, Subchronic toxicity study |
| Safety evaluation of water-soluble palm fruit bioactives |
Regul Toxicol Pharmacol |
Primary, in vivo |
Toxicology, Subchronic toxicity study, Ames test, Chromosomal aberration assay |
| Effects of Unsweetened Preloads and Preloads Sweetened with Caloric or Low-/No-Calorie Sweeteners on Subsequent Energy Intakes: A Systematic Review and Meta-Analysis of Controlled Human Intervention Studies |
Adv Nutr |
Systematic review |
Sweeteners, Study designs |
| Safety evaluation of amylomaltase from Thermus aquaticus |
Regul Toxicol Pharmacol |
Primary, in vivo |
Enzymes, Toxicology, Ames test, Chromosomal aberration assay, Subchronic toxicity study |
| In silico and in vitro safety assessment of a fungal biomass from Rhizomucor pusillus for use as a novel food ingredient |
Food Chem Toxicol |
Primary, in silico |
Bioinformatic analysis |
| Toxicological safety evaluation of a novel highly bioavailable turmeric extract formulation |
J Appl Toxicol |
Primary, in vivo |
Toxicology, Subchronic toxicity study, Genotoxicity, Ames test |
| Safety assessment of miraculin using in silico and in vitro digestibility analyses |
Food Chem Toxicol |
Primary, in silico |
Digestibility Assay, Alternative testing, Allergenicity, Proteomics |
| Clinical safety evaluation of marine oil derived from Calanus finmarchicus |
Regul Toxicol Pharmacol |
Primary, Clinical trial |
Oil, Safety Evaluation |
| Preclinical safety evaluation of triacylglycerol lipase QLM from Burkholderia ubonensis |
Regul Toxicol Pharmacol |
Primary, in vivo |
Toxicology, Subchronic toxicity study, Genotoxicity, Ames test, Chromosomal aberration assay |
| Systematic review and evaluation of aspartame carcinogenicity bioassays using quality criteria |
Regul Toxicol Pharmacol |
Systematic review |
Sweeteners, Food additives |
| Toxicological safety evaluation of the human-identical milk oligosaccharide 6'-sialyllactose sodium salt |
J Appl Toxicol |
Primary, in vivo |
Toxicology, Human milk oligosaccharides (HMO), Dietary fibers, Developmental toxicity, Subchronic toxicity study |
| Dietary Exposures to Common Emulsifiers and Their Impact on the Gut Microbiota: Is There a Cause for Concern? |
Compr Rev Food Sci Food Saf |
Expert Opinion |
Toxicology, Flavouring, Food additives |
| Chewing gum consumption in the United States among children, adolescents and adults |
Food Addit Contam Part A Chem Anal Control Expo Risk Assess |
Intake Assessment |
Dietary exposure |
| Genotoxicity and subchronic toxicity evaluation of dried Euglena gracilis ATCC PTA-123017 |
Regul Toxicol Pharmacol |
Primary, in vivo |
Toxicology, Dietary fibers, Genotoxicity, Subchronic toxicity study, Ames test |
| Vitamin D mushrooms: comparison of the composition of button mushrooms (Agaricus bisporus) treated postharvest with UVB light or sunlight |
J Agric Food Chem |
Primary, chemical analysis |
Vitamins, Whole food |
| An Appetite for Modernizing the Regulatory Framework for Protein Content Claims in Canada |
Nutrients |
Expert Opinion |
Regulatory assessment, Protein, Amino acid |
| In silico evaluation of the potential allergenicity of a fungal biomass from Rhizomucor pusillus for use as a novel food ingredient |
Regul Toxicol Pharmacol |
Primary, in silico |
Bioinformatic analysis, Novel Foods, Allergenicity |
| Chemical-specific adjustment factors (inter-species toxicokinetics) to establish the ADI for steviol glycosides |
Regul Toxicol Pharmacol |
Expert Opinion |
Sweeteners, Pharmacokinetics, Safety Evaluation |
| An open-label, acute clinical trial in adults to assess ketone levels, gastrointestinal tolerability, and sleepiness following consumption of (R)-1,3-butanediol (Avela™) |
Front Physiol |
Primary, Clinical trial |
Safety Evaluation |
| Safety evaluation of a mixture of the human-identical milk oligosaccharides 2'-fucosyllactose and difucosyllactose |
Food Chem Toxicol |
Primary, in vivo |
Dietary fibers, Human milk oligosaccharides (HMO), Toxicology, Subchronic toxicity study, Genotoxicity, Developmental toxicity |
| Acute and subchronic toxicity studies of pyrroloquinoline quinone (PQQ) disodium salt (BioPQQ™) in rats |
Regul Toxicol Pharmacol |
Primary, in vivo |
Toxicology, Subchronic toxicity study, Dietary supplements |
| Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels |
Nutr Res |
Primary, Clinical trial |
Oil, Clinical trials, Natural Health Products, Safety Evaluation |
| In vitro and in vivo assessment of the genotoxic activity of aloesin |
Regul Toxicol Pharmacol |
Primary, in vivo |
Toxicology, Genotoxicity, Ames test |
| In vitro metabolism of rebaudioside B, D, and M under anaerobic conditions: comparison with rebaudioside A |
Regul Toxicol Pharmacol |
Primary, in vitro |
Sweeteners, Pharmacokinetics, Metabolism |
| Low- and no-calorie sweetener intakes from beverages - an up-to-date assessment in four regions: Brazil, Canada, Mexico and the United States |
Food Addit Contam Part A Chem Anal Control Expo Risk Assess |
Primary, Intake Assessment |
Sweeteners, Dietary exposure |
| Toxicological evaluation of a pumpkin-derived pectin preparation: in vitro genotoxicity studies and a 13-week oral toxicity study in Sprague-Dawley rats |
Toxicol Res (Camb) |
Primary, in vivo |
Toxicology, Dietary fibers, Genotoxicity, Subchronic toxicity study, Ames test, Chromosomal aberration assay, Carbohydrates |
| Safety evaluation of highly-branched cyclic dextrin and a 1,4-alpha-glucan branching enzyme from Bacillus stearothermophilus |
Regul Toxicol Pharmacol |
Primary, in vivo |
Toxicology, Dietary fibers, Genotoxicity, Subchronic toxicity study, Carbohydrates |
| Steviol glycosides in purified stevia leaf extract sharing the same metabolic fate |
Regul Toxicol Pharmacol |
Primary, in vitro |
Pharmacokinetics, Metabolism, Food additives, Sweeteners |
| Histological analyses of the Ishii (1981) rat carcinogenicity study of aspartame and comparison with the Ramazzini Institute studies |
Regul Toxicol Pharmacol |
Expert Opinion |
Sweeteners, Food additives, Study designs, Carcinogenicity |
| Safety evaluation of 1,4-alpha-glucan branching enzymes from Bacillus stearothermophilus and Aquifex aeolicus expressed in Bacillus subtilis |
Food Chem Toxicol |
Primary, in vivo |
Toxicology, Enzymes, Subchronic toxicity study, Ames test, Chromosomal aberration assay, Genotoxicity |
| Subchronic and reproductive toxicity of whole dried Hoodia parviflora aerial parts in the rat |
Food Chem Toxicol |
Primary, in vivo |
Dietary supplements, Reproductive toxicity, Subchronic toxicity study, Toxicology |
| Subchronic and reproductive/developmental (screening level) toxicity of complexation products of iron trichloride and sodium tartrate (FemTA) |
J Food Sci |
Primary, in vivo |
Toxicology, Reproductive toxicity, Developmental toxicity, Minerals |
| Method for calculating ADI-derived guidance values for drug carryover levels in medicated feeds |
Regul Toxicol Pharmacol |
Expert Opinion |
Toxicology, Regulatory assessment, Dietary exposure |
| Effects of a Fermented Dairy Drink Containing Lacticaseibacillus paracasei subsp. paracasei CNCM I-1518 (Lactobacillus casei CNCM I-1518) and the Standard Yogurt Cultures on the Incidence, Duration, and Severity of Common Infectious Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
Nutrients |
Systematic review |
Meta-anaysis, Probiotics, Clinical trials, Study designs, Tolerability |
| Genotoxicity of dried Hoodia parviflora aerial parts |
Food Chem Toxicol |
Primary, in vitro |
Toxicology, Genotoxicity, Ames test, Dietary supplements |
| Corrigendum to "Safety assessment of miraculin using in silico and in vitro digestibility analyses" [Food Chem. Toxicol. 133 (2019 Nov) 110762] |
Food Chem Toxicol |
Primary, in vivo |
Digestibility Assay, Bioinformatic analysis |
| A Systematic Review and Meta-Analysis of Randomized Controlled Trials on the Effects of Oats and Oat Processing on Postprandial Blood Glucose and Insulin Responses |
J Nutr |
Systematic review |
Meta-anaysis, Dietary fibers, Clinical trials |
| Genetic and acute toxicological evaluation of an algal oil containing eicosapentaenoic acid (EPA) and palmitoleic acid |
Food Chem Toxicol |
Primary, in vivo |
Oil, Toxicology, Genotoxicity, Ames test |
| Benzoates intakes from non-alcoholic beverages in Brazil, Canada, Mexico and the United States |
Food Addit Contam Part A Chem Anal Control Expo Risk Assess |
Primary, Intake Assessment |
Dietary exposure, Food additives |
| A Randomized, Double-Blind, Placebo-Controlled, Multicentre Trial of the Effects of a Shrimp Protein Hydrolysate on Blood Pressure |
Int J Hypertens |
Primary, Clinical trial |
Clinical trials, Protein, Safety Evaluation |
| Lack of human tissue-specific correlations for rodent pancreatic and colorectal carcinogens |
Regul Toxicol Pharmacol |
Expert Opinion |
Carcinogenicity, Toxicology |
| Safety evaluation of an enzymatically-synthesized glycogen (ESG) |
Regul Toxicol Pharmacol |
Primary, in vivo |
Carbohydrates, Toxicology, Safety Evaluation |
| Assessment of Intakes and Patterns of Cooked Oatmeal Consumption in the U.S. Using Data from the National Health and Nutrition Examination Surveys |
Nutrients |
Primary, Intake Assessment |
Dietary exposure, Dietary fibers, Regulatory assessment |
| Comparison of estimated daily intakes of flavouring substances with no-observed-effect levels |
Food Chem Toxicol |
Primary, in silico |
Flavouring, Food additives, Dietary exposure, Safety Evaluation |
| Technological challenges of addressing new and more complex migrating products from novel food packaging materials |
Food Addit Contam Part A Chem Anal Control Expo Risk Assess |
Expert Opinion |
Novel Foods, Safety Evaluation, Toxicology |
| Systematic review and meta-analysis of controlled intervention studies on the effectiveness of long-chain omega-3 fatty acids in patients with nonalcoholic fatty liver disease |
Nutr Rev |
Systematic review |
Meta-anaysis, Oil, Safety Evaluation, Clinical trials, Study designs |
| The effects of whole-grain compared with refined wheat, rice, and rye on the postprandial blood glucose response: a systematic review and meta-analysis of randomized controlled trials |
Am J Clin Nutr |
Systematic review |
Meta-anaysis, Dietary fibers, Clinical trials, Study designs, Whole food |
| Safety evaluation of a peptide product derived from sardine protein hydrolysates (valtyron) |
Int J Toxicol |
Primary, in vivo |
Toxicology, Safety Evaluation, Protein, Amino acid, Genotoxicity, Ames test |
| An evaluation of the maximized survey-derived daily intake (MSDI) as a practical method to estimate intake of flavouring substances |
Food Chem Toxicol |
Expert Opinion |
Dietary exposure, Safety Evaluation, Food additives, Flavouring |
